Clean, fresh water is fundamental to human health and agricultural production, but populations are rising fastest in parts of the world where water is scarcest, and a vast amount of freshwater is currently extracted for use in crop irrigation, which is lowering water tables. Coupled with climate-change impacts and agricultural water-course pollution, a clean-water availability crisis is mounting – with critical implications for food and nutrition security. This domain explores how agroecological approaches can contribute to inclusive, risk-mitigating management of water resources.